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The translational significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB. Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus.

Recent studies published in PloS Pathogens, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design. Research interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world. More specifically, the reconstitution of the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TB , and pathogenesis such as the Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.

Skip to main content. Most applications do not need this option. Available as of PHP 7. Removed in cURL 7. Request method is then set to HEAD.

Changing this to false does not change it to GET. Note : PHP automatically sets this option to true , this should only be changed for debugging purposes. There is no guarantee this request will be fulfilled, however. Use 0 to wait indefinitely. If libcurl is built to use the standard system name resolver, that portion of the connect will still use full-second resolution for timeouts with a minimum timeout allowed of one second.

This option is set to 2 minutes by default. Defaults to milliseconds. Happy eyeballs attempts to connect to both IPv4 and IPv6 addresses for dual-stack hosts, preferring IPv6 first for timeout milliseconds.

The bitwise or operator can be used to combine more than one method. If this is done, cURL will poll the server to see what methods it supports and pick the best one. If used, this bitmask limits what protocols libcurl may use in the transfer. This allows you to have a libcurl built to support a wide range of protocols but still limit specific transfers to only be allowed to use a subset of them.

By default libcurl will accept all protocols it supports. Note : Your best bet is to not set this and let it use the default. These two options share the same storage and therefore only one of them can be set per handle. Might require an absolute path. Note that multiple cookies are separated with a semicolon followed by a space e. If the name is an empty string, no cookies are loaded, but cookie handling is still enabled.

Available since cURL 7. Do not enter a whole HTTP request line here. Note : Don't do this without making sure the server supports the custom request method first. Set the name of the network interface that the DNS resolver should bind to. This must be an interface name not an address.

Set the local IPv4 address that the resolver should bind to. The argument should contain a single numerical IPv4 address as a string. Set the local IPv6 address that the resolver should bind to. The argument should contain a single numerical IPv6 address as a string. Note : Since this option contains a sensitive password, remember to keep the PHP script it is contained within safe. An array of hostname, port, and IP address strings, each element separated by a colon.

In the format: array "example. The first is the cURL resource, the second is a string with the header data to be written. The header data must be written by this callback. Return the number of bytes written. The first is the cURL resource, the second is a string containing a password prompt, and the third is the maximum password length. Return the string containing the password. The first is the cURL resource, the second is the total number of bytes expected to be downloaded in this transfer, the third is the number of bytes downloaded so far, the fourth is the total number of bytes expected to be uploaded in this transfer, and the fifth is the number of bytes uploaded so far.

Return a non-zero value to abort the transfer. Makes the cURL handle to use the data from the shared handle. Returns true on success or false on failure. Version Description 8. Example 1 Initializing a new cURL session and fetching a web page. Submit a Pull Request Report a Bug. This is turned on by default in multi-threaded SAPIs so timeout options can still be used.

Default bundle installed as of cURL 7. When set to false, the peer certificate verification succeeds regardless.

CURLFile may be used for uploads instead. Default value of 20 is set to prevent infinite redirects. Setting to -1 allows inifinite redirects, and 0 refuses all redirects.

This allows you to limit specific transfers to only be allowed to use a subset of protocols in redirections. This is a difference compared to pre Available as of 7. In production environments the value of this option should be kept at 2 default value. Support for value 1 removed in cURL 7. When set to 0 the connection succeeds regardless of the names used in the certificate.

Use that ability with caution! From curl 7. If set to 0 default keepalive probes are disabled. Not all operating systems support this option. The default is Before cURL 7. Defaults to zero. On systems where 'long' is only 32 bit wide, this option has to be used to set dates beyond the year Defaults to unlimited speed.

This enables decoding of the response. Supported encodings are "identity" , "deflate" , and "gzip". If an empty string, "" , is set, a header containing all supported encoding types is sent. The string may be a plain IP address, a hostname, a network interface name under Unix , or just a plain '-' to use the systems default IP address. This can be an interface name, an IP address or a host name. Any of the following values in order from least to most powerful are valid: "clear" , "safe" , "confidential" , "private".

If the string does not match one of these, "private" is used. Setting this option to null will disable KRB4 security. The string can be the file name of your pinned public key. A numerical IPv6 address must be written within [brackets].

Setting the preproxy to an empty string explicitly disables the use of a preproxy. To specify port number in this string, append :[port] to the end of the host name.

Defaults to using port for proxies if a port is not specified. Set the path as a string naming a file holding one or more certificates to verify the HTTPS proxy with.

Defaults set to the system path where libcurl's cacert bundle is assumed to be stored. You never needed a passphrase to load a certificate but you need one to load your private key.

With NSS or Secure Transport, this can also be the nickname of the certificate you wish to authenticate with as it is named in the security database. If you want to use a file from the current directory, please precede it with ". OpenSSL versions 0. Defaults to "PEM".

The list must be syntactically correct, it consists of one or more cipher strings separated by colons. Commas or spaces are also acceptable separators but colons are normally used,!

The list must be syntactically correct, it consists of one or more cipher suite strings separated by colons. This option is currently used only when curl is built to use OpenSSL 1. Available if built TLS enabled. Supported method is "SRP". By , GPUs had evolved into highly parallel multi-core systems allowing efficient manipulation of large blocks of data.

This design is more effective than general-purpose central processing unit CPUs for algorithms in situations where processing large blocks of data is done in parallel, such as:. In the computer game industry, GPUs are used for graphics rendering, and for game physics calculations physical effects such as debris, smoke, fire, fluids ; examples include PhysX and Bullet.

CUDA has also been used to accelerate non-graphical applications in computational biology , cryptography and other fields by an order of magnitude or more. Mac OS X support was later added in version 2. CUDA is compatible with most standard operating systems. CUDA 8. CUDA GV11B [43] [44].

Note: Any missing lines or empty entries do reflect some lack of information on that exact item. Below is an example given in Python that computes the product of two arrays on the GPU. Additional Python bindings to simplify matrix multiplication operations can be found in the program pycublas. From Wikipedia, the free encyclopedia. Parallel computing platform and programming model. This article uses bare URLs , which may be threatened by link rot. Please consider converting them to full citations to ensure the article remains verifiable and maintains a consistent citation style.

Several templates and tools are available to assist in formatting, such as reFill documentation. June Learn how and when to remove this template message. Further information: Graphics processing unit. Out dest , drv. In a , drv. Tom's Hardware. Retrieved May 17, OpenCL vs. Retrieved Retrieved May 16, Lecture Notes in Computer Science. ISBN BMC Bioinformatics. PMC PMID Archived from the original on